Amod76.5mg+SP262.5mg disp tab/3+1/PAC-50
Amodiaquine 76.5mg (as hydrochloride) + Sulfadoxine-Pyrimethamine 250 mg+ 12.5 mg dispersible tablets, Co-Blister of 3+1 tablets. Packed in a pack of 50 blisters.
Indicative Price 14.59 USD
Amodiaquine 76.5mg (as hydrochloride) + Sulfadoxine-Pyrimethamine 250mg + 12.5mg dispersible tablets Co-Blister /3+1/ PAC -50.
Each Amodiaquine tablet contains Amodiaquine Hydrochloride 100mg, equivalent to Amodiaquine 76.5mg base.
Each SP tablet contains Sulfadoxine 250mg + Pyrimethamine 12.5mg in a ratio of 20:1
Amodiaquine is a 4-Aminoquinolone which interferes with parasite haem detoxification
Sulfadoxine is a slowly eliminated ultra-long acting sulphonamide that competitively inhibits dihydropteroate synthase, the enzyme responsible for the incorporation of Para amino benzoic acid in the synthesis of folic acid
Pyrimethamine is a diaminopyrimidine that inhibits plasmodial dihydrofolate reductase, thus, indirectly blocking the synthesis of parasite nucleic acids.
Sulfadoxine and Pyrimethamine as a combination works by sequentially blocking the two enzymes involved in the biosynthesis of folinic acid in Plasmodium parasites
Standard shelf life
Other available formulations
The product may also be available in other formulations or pack sizes.
Plasmodium falciparum malaria: Seasonal Malaria Chemoprevention (SMC).
Suggested dosing is based on the WHO guidelines for the treatment of Malaria: www.who.int/malaria/publications/atoz/9241546948/en/index.html
Keep out of reach and sight of children.
Store below 30℃.
Dispense in original container. Do not repack
Advice patient to take SP tablets after a meal and with plenty of fluids. Both Amodiaquine and Sulfadoxine+ Pyrimethamine tablets must be taken together on day 1.
Guidelines for use
For more details, please see:
World Health Organisation (WHO), Guidelines for the treatment of Malaria: (www.who.int/malaria/en/)
WHO, Model Lists of Essential Medicines for adults and/or children respectively: (www.who.int/medicines/publications/essentialmedicines/en/index.html)
WHO Model Formulary: http://www.who.int/selection_medicines/list/en/
or your regional and/or national guidelines.
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