S1532008

Amod76.5mg+SP262.5mg disp tab/3+1/PAC-50


Amodiaquine 76.5mg (as hydrochloride) + Sulfadoxine-Pyrimethamine 250 mg+ 12.5 mg dispersible tablets, Co-Blister of 3+1 tablets. Packed in a pack of 50 blisters.
Indicative Price 14.59 USD
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General Description
Amodiaquine 76.5mg (as hydrochloride) + Sulfadoxine-Pyrimethamine 250mg + 12.5mg dispersible tablets Co-Blister /3+1/ PAC -50.

Technical Specifications
Each Amodiaquine tablet contains Amodiaquine Hydrochloride 100mg, equivalent to Amodiaquine 76.5mg base.
Each SP tablet contains Sulfadoxine 250mg + Pyrimethamine 12.5mg in a ratio of 20:1

Therapeutic class
Amodiaquine is a 4-Aminoquinolone which interferes with parasite haem detoxification

Sulfadoxine is a slowly eliminated ultra-long acting sulphonamide that competitively inhibits dihydropteroate synthase, the enzyme responsible for the incorporation of Para amino benzoic acid in the synthesis of folic acid

Pyrimethamine is a diaminopyrimidine that inhibits plasmodial dihydrofolate reductase, thus, indirectly blocking the synthesis of parasite nucleic acids.

Sulfadoxine and Pyrimethamine as a combination works by sequentially blocking the two enzymes involved in the biosynthesis of folinic acid in Plasmodium parasites

Standard shelf life
24 months

Other available formulations
The product may also be available in other formulations or pack sizes.

Indications
Plasmodium falciparum malaria: Seasonal Malaria Chemoprevention (SMC).
http://www.who.int/malaria/publications/atoz/smc_policy_recommendation_e n_032012.pdf

Dosage
Suggested dosing is based on the WHO guidelines for the treatment of Malaria: www.who.int/malaria/publications/atoz/9241546948/en/index.html
http://www.who.int/malaria/publications/atoz/smc_policy_recommendation_e n_032012.pdf

Storage
Keep out of reach and sight of children.
Store below 30℃.

Dispensing instructions
Dispense in original container. Do not repack
Advice patient to take SP tablets after a meal and with plenty of fluids. Both Amodiaquine and Sulfadoxine+ Pyrimethamine tablets must be taken together on day 1.

Guidelines for use
For more details, please see:
World Health Organisation (WHO), Guidelines for the treatment of Malaria: (www.who.int/malaria/en/)
WHO, Model Lists of Essential Medicines for adults and/or children respectively: (www.who.int/medicines/publications/essentialmedicines/en/index.html)
WHO Model Formulary: http://www.who.int/selection_medicines/list/en/
or your regional and/or national guidelines.



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