Amod 153mg+ SP 525mg disp tab/3+1/PAC-50

Amodiaquine 153mg (as hydrochloride) + Sulfadoxine-Pyrimethamine 500 mg+ 25 mg dispersible tablets Co-Blister of 3+1 tablets. Packed in a pack of 50 blisters.
Indicative Price 16.25 USD
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General Description
Amodiaquine 153mg (as hydrochloride) + Sulfadoxine-Pyrimethamine 500mg + 25mg dispersible tablets Co-Blister /3+1/ PAC -50.

Technical Specifications
Each Amodiaquine tablet contains Amodiaquine Hydrochloride 200mg, equivalent to Amodiaquine 153mg base.
Each SP tablet contains Sulfadoxine 500mg + Pyrimethamine 25mg in a ratio of 20:1

Therapeutic class
Amodiaquine is a 4-Aminoquinolone which interferes with parasite haem detoxification

Sulfadoxine is a slowly eliminated ultra long acting sulphonamide that competitively inhibits dihydropteroate synthase, the enzyme responsible for the incorporation of Para amino benzoic acid in the synthesis of folic acid

Pyrimethamine is a diaminopyrimidine that inhibits plasmodial dihydrofolate reductase, thus, indirectly blocking the synthesis of parasite nucleaic acids.

Sulfadoxine and Pyrimethamine as a combination works by sequentially blocking the two enzymes involved in the biosynthesis of folinic acid in Plasmodium parasites

Standard shelf life
24 months

Other available formulations
The product may also be available in other formulations or pack sizes.

Plasmodium falciparum malaria: Seasonal Malaria Chemoprevention (SMC).
http://www.who.int/malaria/publications/atoz/smc_policy_recommendation_e n_032012.pdf

Suggested dosing is based on the WHO guidelines for the treatment of Malaria: www.who.int/malaria/publications/atoz/9241546948/en/index.html
http://www.who.int/malaria/publications/atoz/smc_policy_recommendation_e n_032012.pdf

Keep out of reach and sight of children.
Store below 30℃.

Dispensing instructions
Dispense in original container. Do not repack
Advice patient to take SP tablets after a meal and with plenty of fluids.
Both Amodiaquine and Sulfadoxine+ Pyrimethamine tablets must be taken together on day 1.

Guidelines for use
For more details, please see:
World Health Organisation (WHO), Guidelines for the treatment of Malaria: (www.who.int/malaria/en/)
WHO, Model Lists of Essential Medicines for adults and/or children respectively: (www.who.int/medicines/publications/essentialmedicines/en/index.html)
WHO Model Formulary: http://www.who.int/selection_medicines/list/en/
or your regional and/or national guidelines.
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