Sulfadox+Pyrimeth 500+25mg tabs/PAC-100
Sulfadoxine 500mg + Pyrimethamine 25mg tablets, pack of 100.
Indicative Price 9.25 USD
Sulfadoxine 500mg + Pyrimethamine 25mg uncoated tablets, bottle pack of 100
Each uncoated tablets contains Sulfadoxine 500mg + Pyrimethamine 25mg in a ratio of 20:1
Sulfadoxine is a slowly eliminated ultra long acting sulphonamide that competitively inhibits dihydropteroate synthase, the enzyme responsible for the incorporation of Para amino benzoic acid in the synthesis of folic acid
Pyrimethamine is a diaminopyrimidine that inhibits plasmodial dihydrofolate reductase, thus, indirectly blocking the synthesis of parasite nucleaic acids.
Sulfadoxine and Pyrimethamine as a combination works by sequentially blocking the two enzymes involved in the biosynthesis of folinic acid in Plasmodium parasites.
Standard shelf life
Guidelines for use
For more details, please see:
World Health Organisation (WHO), Guidelines for the treatment of Malaria: http://www.who.int/malaria/publications/atoz/9789241549127/en/
WHO, Model Lists of Essential Medicines for adults and/or children respectively:
WHO Model Formulary:
http://apps.wh o.int/medicinedocs/en/d/Js16879e/ or your regional and/or national guidelines.
Treatment of falciparum malaria, in combination with other antimalarials.
Prevention of malaria in pregnancy caused by P. falciparum alone or with other Plasmodium spp. (Intermittent preventive treatment - IPT). For more details on Malaria in pregnancy, see http://www.who.int/malar ia/areas/preventive_therapies/pr egnancy/en/
Treatment of toxoplasmosis in HIV positive patients.
By mouth (oral)
Do not store above 30 °C
Store in original packaging
Keep out of the reach and sight of children.
Protect from light
Advice patient to take SP tablets after a meal and with plenty of fluids.
Advice patient to avoid excessive exposure to direct sunshine.
This material is part of the Emergency Supply List.
Oral suspension may be available in some markets, but with stability challenges
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