Sulfadox+Pyrimeth 500+25mg tabs/PAC-1000

Sulfadoxine 500mg + Pyrimethamine 25mg tablets, pack of 1000.
Indicative Price 75.89 USD

General Description:
Sulfadoxine 500mg + Pyrimethamine 25mg uncoated tablets, bottle pack of 1000

Technical Specifications:
Each uncoated tablets contains Sulfadoxine 500mg + Pyrimethamine 25mg in a ratio of 20:1

Therapeutic class:
Sulfadoxine is a slowly eliminated ultra long acting sulphonamide that competitively inhibits dihydropteroate synthase, the enzyme responsible for the incorporation of Para amino benzoic acid in the synthesis of folic acid.

Pyrimethamine is a diaminopyrimidine that inhibits plasmodial dihydrofolate reductase, thus indirectly blocking the synthesis of parasite nucleaic acids.

Sulfadoxine and Pyrimethamine as a combination works by sequentially blocking the two enzymes involved in the biosynthesis of folinic acid in Plasmodium parasites.

Standard shelf life:
2 years (24 months)

Guidelines for use:
For more details, please see the links listed below:

WHO Guidelines for the treatment of Malaria


WHO Model Lists of Essential medicines for adults and/or children

http:/ /www.who.int/selection_medicines/list/WMF2008.pdf

or consult your regional/national guidelines

Treatment of falciparum malaria in combination with other antimalarials. Prevention of malaria in pregnancy caused by P. falciparum alone or with other Plasmodium spp. (Intermittent preventive treatment - IPT). For more details on Malaria in pregnancy, see
http://www.who.int/malaria/areas/preventive_therapies/pr egnancy/en/
Treatment of toxoplasmosis in HIV positive patients.
By mouth (oral)

Store at temperatures not exceeding 25°C (77°F). Excursions permitted to 15-30°C (59-86°F).
Store in original packaging
Keep out of the reach and sight of children.
Protect from light.

Dispensing instructions:
Advise patient to take SP tablets after a meal and with plenty of fluids.
Advise patient to avoid excessive exposure to direct sunshine.

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